環保專案成果報告查詢系統

專案計畫編號	EPA-98-E3S4-02-03
經費年度	098
計畫經費	1,660 千元
專案開始日期	2009/01/22
專案結束日期	2009/12/31
專案主持人	陳家揚副教授
主辦單位	環檢所
承辦人
執行單位	國立台灣大學公共衛生學院環境衛生研究所
專案分類	環境監測及檢測
中文關鍵字	個人保健品；液相層析串連式質譜儀；生活污水；表面水；固相萃取
英文關鍵字	Personal care products；LC/MS/MS；Sewage；surface water；Solid-phase extraction
協同主持人	龍世俊副研究員
共同主持人
計畫聯絡人	陳家揚
計畫聯絡電話	02-33668101#
計畫聯絡信箱	dbms@ntu.edu.tw

中文摘要	個人保健品為日常生活中民眾基於健康照護、提神、美容、殺菌等目的而使用之個人或居家用品。這些藥品或成分於使用後或是因任意棄置，可經由多重管道進入環境中，且目前已可在表面水體中可測得微量的存在。雖然水體中測得的濃度不高，但其對於水中生物或人類健康的影響仍然值得持續關注。　　本計畫針對8種鎮痛解熱劑、4種荷爾蒙及作用類似物，2種清潔用品，2種防曬劑，2種美容用品，及驅蟲劑，興奮劑，保健食品與草藥類各1種等八大類共21種化合物，完成水樣前處理技術開發以及液相層析/質譜/質譜儀分析方法建立。水樣以PolarPlus C18 （50 mm）固相萃取圓盤萃取，沖提液經濃縮回溶後，以極致液相層析儀（ultra-performance liquid chromatography, UPLC）搭配串聯式質譜儀分析。正電荷離子使用UPLC HSS T3（50 × 2.1 mm, 1.8 μm）管柱分析，負電荷則為UPLC BEH C18（50 × 2.1 mm, 1.7 μm）。採樣地點為中部主要河川中港溪、烏溪及北港溪以及北部兩座二級汙水處理廠之進流水、初級處理後污水及放流水共計27個水體樣本。水體檢測結果顯示，ibuprofen、acetylsalicylic acid、fenoprofen、nonylphenol (NP)、oxybenzone、DEET、caffeine、methyl paraben、butyl paraben於表面水體檢出率高（>76%）。以濃度來看，ibuprofen、 NP、oxybenzone及caffeine等化合物較高，最高濃度分別為1,483 ng/L，837 ng/L，783 ng/L及3,007 ng/L。顯示多種個人保健品已存在於中部的河川流域。在兩污水處理廠的進流水樣本中，以acetaminophen與caffeine濃度最高，兩廠分別為7,509 ng/L、10,928 ng/L及6,866 ng/L、22,966 ng/L。B廠對兩化合物的移除效果佳（>99%）。
中文關鍵字	個人保健品；液相層析串連式質譜儀；生活污水；表面水；固相萃取

中文摘要

個人保健品為日常生活中民眾基於健康照護、提神、美容、殺菌等目的而使用之個人或居家用品。這些藥品或成分於使用後或是因任意棄置，可經由多重管道進入環境中，且目前已可在表面水體中可測得微量的存在。雖然水體中測得的濃度不高，但其對於水中生物或人類健康的影響仍然值得持續關注。　　本計畫針對8種鎮痛解熱劑、4種荷爾蒙及作用類似物，2種清潔用品，2種防曬劑，2種美容用品，及驅蟲劑，興奮劑，保健食品與草藥類各1種等八大類共21種化合物，完成水樣前處理技術開發以及液相層析/質譜/質譜儀分析方法建立。水樣以PolarPlus C18 （50 mm）固相萃取圓盤萃取，沖提液經濃縮回溶後，以極致液相層析儀（ultra-performance liquid chromatography, UPLC）搭配串聯式質譜儀分析。正電荷離子使用UPLC HSS T3（50 × 2.1 mm, 1.8 μm）管柱分析，負電荷則為UPLC BEH C18（50 × 2.1 mm, 1.7 μm）。採樣地點為中部主要河川中港溪、烏溪及北港溪以及北部兩座二級汙水處理廠之進流水、初級處理後污水及放流水共計27個水體樣本。水體檢測結果顯示，ibuprofen、acetylsalicylic acid、fenoprofen、nonylphenol (NP)、oxybenzone、DEET、caffeine、methyl paraben、butyl paraben於表面水體檢出率高（>76%）。以濃度來看，ibuprofen、 NP、oxybenzone及caffeine等化合物較高，最高濃度分別為1,483 ng/L，837 ng/L，783 ng/L及3,007 ng/L。顯示多種個人保健品已存在於中部的河川流域。在兩污水處理廠的進流水樣本中，以acetaminophen與caffeine濃度最高，兩廠分別為7,509 ng/L、10,928 ng/L及6,866 ng/L、22,966 ng/L。B廠對兩化合物的移除效果佳（>99%）。

中文關鍵字

個人保健品；液相層析串連式質譜儀；生活污水；表面水；固相萃取

類型	檔名	檔案大小	說明	最新版公開日期
期末報告	98期末報告書_定稿本20091115.pdf	8MB		2010/5/1 上午 12:00:00

摘要	Personal care products (PCPs) are used for daily health care, refreshment, cosmetology, and disinfection etc. The compounds or products may be disposed improperly then enter the environment. Although the concentrations of PCPs were usually at trace amount in waters, it is still a concern on their potential adverse effects on aquatic creatures and human health. This project targeted 21 critical chemicals at eight categories, including eight analgesics, four hormones, two ingredients in detergent/disinfectant, two agents in suntan lotions, two preservatives in cosmetics, one repellent, one stimulant, and one health food with herbal medicine. A method to extract them from water and followed by the determination using ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) with electrospray ionization (ESI) has been developed and validated. Water samples were extracted with 50 mm PolarPlus C18 speedisk using automatic solid phase extraction system. The eluent was concentrated to barely dryness and re-dissolved by methanol/water (1:4, v/v). Analytes forming positive ions were separated on a UPLC HSS T3 column (50 × 2.1 mm, 1.8 μm), and chemicals forming negative ions were done on a UPLC BEH C18 column (50 × 2.1 mm, 1.7 μm). Water samples were collected from 21 representative points of three main streams in the middle of Taiwan. In addition, wastewater samples from influents, after primary treatment, and effluents were grabbed from two wastewater treatment plants in Northern Taiwan. The compounds of ibuprofen, acetylsalicylic acid, fenoprofen, nonylphenol (NP), oxybenzone, DEET, caffeine, methyl paraben, and butyl paraben were detected in more than 76% of surface water samples. The highest concentrations found were ibuprofen 1,483 ng/L; NP 837 ng/L; oxybenzone 783 ng/L; and caffeine 3,007 ng/L. Thus, PCPs would have been widely distributed in rivers of middle Taiwan. The highest concentrations found in influent were acetaminophen and caffeine, which were 7,509 and 10,928 ng/L, respectively in a plant as well as 6,866 ng/L and 22,966 ng/L, respectively in the other plant. However, acetaminophen and caffeine could be effectively removed, especially at plant B (>99%).
英文關鍵字	Personal care products；LC/MS/MS；Sewage；surface water；Solid-phase extraction

摘要

Personal care products (PCPs) are used for daily health care, refreshment, cosmetology, and disinfection etc. The compounds or products may be disposed improperly then enter the environment. Although the concentrations of PCPs were usually at trace amount in waters, it is still a concern on their potential adverse effects on aquatic creatures and human health. This project targeted 21 critical chemicals at eight categories, including eight analgesics, four hormones, two ingredients in detergent/disinfectant, two agents in suntan lotions, two preservatives in cosmetics, one repellent, one stimulant, and one health food with herbal medicine. A method to extract them from water and followed by the determination using ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) with electrospray ionization (ESI) has been developed and validated. Water samples were extracted with 50 mm PolarPlus C18 speedisk using automatic solid phase extraction system. The eluent was concentrated to barely dryness and re-dissolved by methanol/water (1:4, v/v). Analytes forming positive ions were separated on a UPLC HSS T3 column (50 × 2.1 mm, 1.8 μm), and chemicals forming negative ions were done on a UPLC BEH C18 column (50 × 2.1 mm, 1.7 μm). Water samples were collected from 21 representative points of three main streams in the middle of Taiwan. In addition, wastewater samples from influents, after primary treatment, and effluents were grabbed from two wastewater treatment plants in Northern Taiwan. The compounds of ibuprofen, acetylsalicylic acid, fenoprofen, nonylphenol (NP), oxybenzone, DEET, caffeine, methyl paraben, and butyl paraben were detected in more than 76% of surface water samples. The highest concentrations found were ibuprofen 1,483 ng/L; NP 837 ng/L; oxybenzone 783 ng/L; and caffeine 3,007 ng/L. Thus, PCPs would have been widely distributed in rivers of middle Taiwan. The highest concentrations found in influent were acetaminophen and caffeine, which were 7,509 and 10,928 ng/L, respectively in a plant as well as 6,866 ng/L and 22,966 ng/L, respectively in the other plant. However, acetaminophen and caffeine could be effectively removed, especially at plant B (>99%).

英文關鍵字

Personal care products；LC/MS/MS；Sewage；surface water；Solid-phase extraction