| 英文摘要 |
Nanomaterials and nanoparticles have received considerable attention for the past decade due to their unique properties and diverse applications in technology and life sciences. Despite the widespread use of nanomaterial products, relatively few studies have been undertaken to determine the biological effects of nanoparticle exposure. Accumulating evidences have suggested that nanoparticles exhibit cytotoxicity and genotoxicity in both in vivo and in vitro studies. Given the increasing use of nanoparticles in a range of products, it has become crucial to develop a fundamental understanding of the biological effect of nanoparticle exposure. Currently, nanoparticles toxicity testing is based on in vitro studies using cell culture system; however, many problems are found to be associated with these testing systems. The purpose of this project is to establish a fast screening platform to evaluate the cytotoxicity of nanoparticles that may expose human by inhalation, dermal absorption, and ingestion. This innovative screening platform is expected to replace traditional in vitro tests with more accuracy, higher sensitivity, and faster screening. Furthermore, similar experiments are conducted in traditional cytotoxicity assays. The comparison will be made to those different assays.
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