環境資源報告成果查詢系統

污染場址土壤中重金屬生物可及性於孩童風險評估模式之應用

中文摘要 土壤、灰塵中的有害物質能透過直接吸入、攝入及皮膚接觸進入人體並造成有害的健康效應。由於幼兒生理及心理上的因素，造成其不但較易暴露到污染土壤且對有害污染物之耐受力也較低。過去的計畫已成功地建立了0~6歲年幼幼童本土化的土壤、灰塵的攝入量及部分與皮膚接觸相關的暴露參數，並建立了與美國環保署相關單位良好的溝通平台。本年度的計畫為擴充調查污染場址暴露參數之生物可及性，選定24個污染場址採集土壤樣品進行評估，並輔以部分動物實驗與生物可及性進行實證資料的比對，研析污染場址中鎘之生物可及性及生物有效性，以應用於健康風險評估系統推估，本計畫53個土壤樣本中，pH值(4.24–7.38)、有機碳含量(0.48–6.06%)及質地等級涵蓋範圍大(砂質壤土、壤質砂土、黏質壤土、坋砂黏土、坋砂質壤土、壤土及砂質黏壤土)，在體外消化系統法簡化生物可及性萃取法SBET中六種元素之平均生物可及性分別為Cd：63%，Cr：17%，Cu：66%，Ni：23%，Pb：50%，Zn：35%，動物實驗之相對生物有效性的結果中腎臟為 34.46±18.87%。SBET除了與重金屬全量有關外，亦與重金屬在土壤中的分配相態及基本特性有關，複迴歸統計結果顯示，土壤pH值、有機質、黏粒是影響SBET的主要因子。在SBET、PBET、0.1 N HCl 和DTPA四種方法中，SBET與0.1 N HCl及PBET方法間有良好的相關性，建議採用費用較低的SBET方法有助於污染土壤中金屬生物可及性的評估。
中文關鍵字 本土化暴露參數、生物可及性、生物有效性、健康風險評估

基本資訊

專案計畫編號 EPA-106-GA11-13-A171 經費年度 106 計畫經費 6850 千元
專案開始日期 2017/04/11 專案結束日期 2018/10/10 專案主持人 簡伶朱
主辦單位 土污基管會 承辦人 王子欣 執行單位 臺北醫學大學

成果下載

類型 檔名 檔案大小 說明
期末報告 EPA106GA1113A171.pdf 26MB 報告書定稿

Bioaccessibility of heavy metals in soils of contaminated sites and its application on health risk assessment for children

英文摘要 Harmful substances in soil and dust may enter into human body through direct inhalation, digestion, and dermal contact causing adverse health effects. Owing to the difference in physical and physiological behaviors, infants and toddlers are not only easier to expose to toxic substances in soil, but also less tolerant to toxic substances than adults. Therefore, toxic substances will pose higher risk to children. We have already acquired the soil/dust ingestion data of 0~6 years old children and some parameters pertaining to dermal contact in the past programs, as well as establishing a good communication channel with the US Environmental Protection Agency (USEPA). This year, the program will focus on supplementing the data of localized exposure parameters, such as bioaccessibility of metals in soil; therefore, we plan to collect soil samples in twenty four soil contaminated sites. To assess the suitability of in vitro assays to predict Cd bioavailability in contaminated soils by correlating Cd bioaccessibility with Cd- relative bioavailability in contaminated soils. Then, apply in the bioaccessibilities of different hazardous elements in contaminated soil for estimating the health risk of containment soil. In this study, the range of pH value, broad ranges in the contents of organic matter and clay of soil samples were shown among the 53 contaminated soils. The pH value ranged from 4.24 to 7.38. The content of organic matter ranged from 0.48 to 6.06%. The content of clay ranged from 6.48 to 42.3%. Based on the in-vitro digestion method, i.e., simple bioaccessibility extraction test (SBET), the average bioaccessibility of Cd, Cr, Cu, Ni, Pb, and Zn is 63%, 17%, 66%, 23%, 50%, and 35%, respectively.Cd-RBA was comparable at 34.46±18.87% based on mouse kidney. The results of multiple linear regression model showed that the types and motilities of the metals, pH, organic matter content, and clay content of soil had significant impacts on the SBET bioaccessibility of metals. SBET had better correlated with 0.1 N HCl extraction and PBET. Our data suggested that inexpensive SBET assay might be useful in estimating the metals bioaccessibility in contaminated soils.
英文關鍵字 Local exposure factors, Bioaccessibility, Bioavailability, Health risk assessment