| 英文摘要 |
This program established and evaluated the technical specifications for the efficacy testing of environmental drugs, environmental drug application, approval, release, and management by trying out the environmental drug efficacy test methods, specifications, and equipment established in 2017, reviewing the applicability of the human chemical mosquito repellent efficacy test methods in 2018, and researching new dosage forms and applications of environmental drug products.
Based on the environmental drug efficacy test methods and bait formulation test equipment established in 2017, three emulsions of each drug, including ultra-low volume emulsions, bait formulations, and gel bait formulations, were tested and reviewed for applicability. The test results showed that the emulsions could be applied to flying insects (Aedes albopictus, Aedes aegypti, Culex quinquefasciatus, Musca domestica, and Drosophila melanogaster) and crawling insects (Blattella germanica, Periplaneta americana, ants and fleas) by the glass column method, the glass chamber method, and the glass room method. The emulsions could also be applied to crawling insects (Blattella germanica, Periplaneta americana, ants, fleas, and Cimex lectularius) by the residual contact method. Three ultra-low volume emulsions could be applied to flying insects (Aedes albopictus, Aedes aegypti, Culex quinquefasciatus, and Musca domestica) and crawling insects (Blattella germanica and Periplaneta americana) by the glass room method, and three bait formulations and gel bait formulations could be applied to crawling insects (cockroaches and ants) using bait devices. The human chemical mosquito repellent efficacy test methods (human hand test, animal test, and artificial vascular membrane) established in 2018 were used to test two human chemical mosquito repellents (DEET 7.0% and Picaridin 20.6%), and full protection effects (feeding rate: 0.00%) were achieved, indicating that the control effects specified on the products could be tested. In addition, the new smoke agents and suspending agents were tested by the glass room method and the WHO cone bioassay contact method, respectively, to learn the applicability to flying insects, and were tested by the residual contact method to learn the applicability to crawling insects. Powders were tested by the contact method to learn the applicability to flying insects (Musca domestica) and crawling insects (Blattella germanica, Periplaneta americana, and ants). In so doing, the technical specifications for the efficacy testing of three new dosage forms of drugs were established. Seven Tessaratoma papillosa efficacy test methods were collected for this research. The program was 100% completed and met the final report progress of 100%.
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