| 英文摘要 |
Until now, more than twenty thousand chemical substances have been used in industries and technologies. The efficient management of the increasing chemical substances is relatively important than ever before. There is a critical need for reliable toxicity-testing methods to identify, assess, and interpret the hazardous properties of any substance. However, traditional toxicity testing is time consuming, high cost, and high manpower. Thus, to increase the efficiency of risk management, this project utilized the amount of chemical manufacture and import to combine with ToxPi-GIS system, including the sensitive population, land-use, and environmental pollutants data. Furthermore, this project applied the high-throughput chemistry and toxicity method for screening effluent samples from the technical industry and tried to develop faster screening tools for evaluating the chemical exposure and human toxicity.
This report includes four major parts, which showed as follows, (1) To apply the cheminformatics in building the prediction data for existing chemical substances, (2) To apply a high-throughput toxicity screening model and chemical analysis in identifying the chemical substance and toxicity in an industry, (3) To build a principle of classification for 35 organotin compounds by read-across and computer-based predictive analysis, (4) To hold an international workshop on environmental hazard identification and exposure assessment of multi-chemical substances. For part 1, we proposed the priority management chemical substances list and visualized by ToxPi-GIS, which can enhance the management of risk assessment in the future. In the part 2, we finished the high-throughput chemical and toxicity analysis and found the four sampling sites should be noticed in the future. The part 3 finished the classification principle of organotin compounds and it can be used for conduct manage policy in future. In the part 4, the international workshop was held on January 9th to January 13th. Four professors were invited from Superfound center of Texas A＆M and more than 90 participants join the workshop for environmental hazard identification and exposure assessment of multi-chemical substances.
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