| 英文摘要 |
The goal of this project is to develop standard compounds for organic chemical synthesis of polyfluorinated compounds. We have conducted a literature review and analyzed synthesis routes for these types of compounds, comparing the advantages and disadvantages of using hydrocarbon-based initiators and fluorocarbon-based initiators in organic synthesis. Simultaneously, we have carried out the synthesis of target compounds. We have successfully synthesized three target compounds: perfluorobutanesulfonyl amidoacetic acid (B), 2 -(N methyl-perfluorobutanesulfonyl amido) acetic acid (D), and N methyl perfluorobutylsulfonyl amidoethanol (E). Their structures have been confirmed through nuclear magnetic resonance and high-resolution mass spectrometry. Furthermore, we have established a highly efficient liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) analysis method for the rapid and reliable detection of these target compounds. The analysis of these three target compounds using electrospray ionization in negative mode (ESI negative ) yields the following results: Perfluorobutanesulfonyl amidoacetic acid (B): Precursor ion at 356 m/z [M-H]-, Daughter ion at 298 and 219 m/z. 2-(N-methyl-perfluorobutanesulfonyl amido) acetic acid (D): Precursor ion at 370 m/z [M-H]- , Daughter ion at 283 and 219 m/z. N-methyl perfluorobutylsulfonyl amidoethanol (E): Precursor ion at 358 m/z [M+H]+ , Daughter ion at 340,131,69, and 57 m/z. The lowest detectable limit (MDL) for FBSAA (B) is 0.014 μg/L, and the lowest detectable limit for MeFBSAA (D) is 0.006 μg/L.
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